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KMID : 0366919950070010044
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Sungkyun Pharmceutical Journal
1995 Volume.7 No. 1 p.44 ~ p.48
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Synthesis of New Quinolone Derivatives via Palladium-catalyzed cross-coupling reactions (Ⅱ)
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Abstract
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Abstract - Palladium catalyzed cross-coupling reactions of aryl halides with organo tin reagents and π-sufficient aromatic heterocycles proceeded easily and efficiently during carbon-carbon bond formation. We used this method for the anti bacterial agents, and synthesis of new quinolone derivatives which have C-C bond at C-7 position of general quinolone moieties. Quinolone moieties, and aryl tin or aromatic heterocycles in the presence of palladium catalyst were coupled to afford new quinolone derivatives. The synthesis and structure-activity relationship are presented.
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KEYWORD
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